Take I-5 South & Take the OR-22/OR-99 Bus Exit, Exit 253 Toward Detroit Lake / Bend. Taking a Left OR-22/OR-99 for 80.4 Miles. OR-22 becomes US-20 E/OR-126 for 26 Miles. Welcome to Sisters!
Go East on 7th Ave/OR-99/OR-126 Bus Toward Pearl St. Continue to follow E 7th Ave. Take I-105 E ramp toward I-5/Springfield/Portland. Merge onto OR-126. Turn left onto Main St/OR-126 & Continue on OR-126 for 68.28 Miles. Turn slight right on US-20 E/OR-126/Santiam HWY. Continue for 28.87 Miles. Welcome to Sisters!